Neurons depend on relentless ATP output and balanced neurotransmitter pools to sustain memory and executive speed. Oxidative strain and cortical inflammation erode these reserves decades before symptoms appear. Lion’s mane and resveratrol up-regulate BDNF, encouraging dendritic branching and antioxidant defense. Theanine, magnesium bisglycinate, and adaptogenic ashwagandha smooth glutamatergic spikes and cortisol swings that cloud cognition.