Oxidative stress and mitochondrial stalling degrade axons and strip myelin, producing neuropathic pain and weakness. Reviving cellular energy and growth factors preserves nerve integrity. Carnitine and alpha-lipoic acid regenerate acetyl-CoA and glutathione, and CoQ10 restores electron-transport efficiency for sustained ATP output. Lion’s mane supplies erinacines that elevate nerve growth factor, encouraging remyelination and sensory recovery.