Entheogenic sessions place extraordinary metabolic and emotional load on the brain–liver axis. Strategic neurotrophic and detox nutrients enhance both the immediate “set and setting” and the integration phase afterward. Theanine calms pre-journey anticipatory anxiety, while lion’s mane stimulates BDNF, priming neuroplasticity for lasting insights. Milk-thistle silymarin safeguards hepatocytes processing alkaloid metabolites; NAC and a micro-dose of melatonin conclude the blend by quenching free radicals and supporting post-experience sleep consolidation.