Particulate inhalation floods alveoli with reactive oxidants that tax glutathione reserves and inflame bronchial tissue. Rapid antioxidant replenishment protects epithelial integrity and clears xenobiotics from phase-II detox pathways. NAC restocks intracellular glutathione, while quercetin and turmeric down-regulate NF-κB, quelling cytokine storms in airway linings. Methyl B-complex with milk-thistle silymarin accelerates hepatic conjugation, and vitamin C plus omega-3s reinforce membrane resilience against further oxidative hits.