Chronic psychosocial load over-activates the HPA axis, elevating cortisol and depleting dopamine and serotonin precursors. Balancing this neuro-endocrine loop restores mood stability and physical stamina. Ashwagandha and theanine smooth cortisol spikes, while magnesium buffers NMDA-receptor excitability that amplifies tension. Methyl B-complex, omega-3s, and cordyceps collectively rebuild neurotransmitter pools and mitochondrial output for calm, sustained energy.